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Our Team

We are pleased to introduce you to the Precision Periodontics team: Dr. Sima, Alina, and Maygan.

We all love the beautiful outdoors of the Reno-Tahoe area and spending quality time with our families.

We are dedicated to our motto "We Rise by Lifting Others" by giving our best to meet your and your dentist's expectations for elevating your smile.

We hope you'll join us on the journey to a healthier you!

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Corneliu Sima DMD MSc DSc

Periodontist & Implant Surgeon

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csima@precision-periodontics.com

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Alina Bochis

Patient Coordinator & Surgical Assistant

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alina.bochis@precision-periodontics.com

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Maygan Herrin

Lead Surgical Assistant

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maygan.herrin@precision-periodontics.com

Professional Achievements

Corneliu Sima, DMD, MSc, DSc

Clinical & Academic Appointments

  • Periodontist & Implant Surgeon, Harvard Dental Center, Boston, MA (2018-2022)

  • Assistant Professor of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine (2018-2022)

  • Periodontist & Implant Surgeon, Forsyth Faculty Associates, Forsyth Institute, Cambridge, MA (2015-2018)

  • Assistant Clinical Investigator, Forsyth Clinical & Translational Research Center, Cambridge, MA (2015-2018)

  • Periodontics & Implant Surgery Resident, University of Toronto Faculty of Dentistry, ON, Canada (2011-2014)

  • Master of Science (Periodontology), Matrix Dynamics Group, University of Toronto, ON, Canada (2011-2014)

  • Oral Surgery Extern, Boston Children's Hospital, Harvard Medical School affiliate, Boston, MA (2009)

  • Oral Surgery Extern, Boston Medical Center, Boston University, Boston, MA (2008-2010)

  • Doctor of Science (Oral Biology), Henry M Goldman School of Dental Medicine, Boston University (2007-2010)

  • Dentist, Swedish Smile private practice, Brasov, BV, Romania (2006-2007)

  • Doctor of Dental Medicine (DMD), Iuliu Hatieganu UMF, School of Dental Medicine, Cluj, Romania (2000-2006)

Clinical Excellence Awards & Honors

  • Erasmus Scholarship, University of the Mediterranean, Marseille, France (2005)

  • Award for Excellence, GlaxoSmithKline (2006)

  • Valedictorian, Iuliu Hatieganu UMF, School of Dental Medicine (2006)

  • Best Student Award, Iuliu Hatieganu UMF, School of Dental Medicine (2000–2006)

  • Diplomate of the International Congress of Oral Implantologists (2014)

  • Diplomate of The American Board of Periodontology (2015)

  • Excellence in Mentoring Awards nomination, Harvard Medical School (2021)

Research Excellence Awards & Honors

  • 1st Place Student Research Award – Senior Basic Science, Canadian Association for Dental Research (2013)

  • Hatton Award Finalist (Unilever), International Association for Dental Research (IADR) (2009, 2014)

  • NIH K99/R00 Award to study Macrophage Regulation of Inflammation in Type II Diabetes-Associated Periodontitis, Dr. Sima as Principal Investigator (2015-2021)

  • NIH SBIR Award (Small Business Innovation Research) to Physical Sciences Inc. to study Raman Microspectroscopy/Micro-Optical Coherence Tomography Probe for Real-Time Assessment of Periodontal Health Status, Dr. Sima as Co-Investigator (2018-2021)

  • NIH R01 Award to Dr. Xiaozhe Han to study Regulatory B Cells in Periodontal Disease, Dr. Sima as Co-Investigator (2019-2021)

Publications

Theses & Dissertations

  • Sima, C. Resolvin E1 Actions on Polymorphonuclear Neutrophils in Diabetes. Dissertation. Boston University, Henry M. Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, 2010.

  • Sima, C. Rac-Null Leukocytes Are Associated with Increased Inflammation-Mediated Alveolar Bone Loss. Thesis. University of Toronto, Faculty of Dentistry, Department of Periodontology, 2014.

Peer Reviewed Original Research

  • Sima C, Rhourida K, Van Dyke TE and Gyurko R. Type 1 Diabetes Predisposes to Enhanced Gingival Leukocyte Margination and Macromolecule Extravasation In Vivo. Journal of Periodontal Research 2010; 45(6): 748–756.

  • Osuchowski MF, Craciun FL, Schuller E, Sima C, Gyurko R, and Remick DG. Untreated Type 1 Diabetes Increases Sepsis-Induced Mortality without Inducing a Prelethal Cytokine Response. Shock 2010; 34(4): 369–376.

  • Rajshankar D, Sima C, Wang Q, Goldberg SR, Kazembe M, Wang Y, Glogauer M and McCulloch C. Role of Ptpα in the Destruction of Periodontal Connective Tissues. PloS One 2013; 8(8): e70659.

  • Sima C, Gastfreud S, Sun C, Glogauer M. Rac Null Leukocytes are Associated with Increased Inflammation-Mediated Alveolar Bone Loss. American Journal of Pathology 2014; 184(2):472-82.

  • Jiang H, Wang Y, Viniegra A, Sima C, McCulloch CA, Glogauer M. Adseverin Plays a Role in Osteoclast Differentiation and Periodontal Disease-Mediated Bone Loss. The FASEB Journal 2015; 29:2281–2291.

  • Sima C, Cheng Q, Rautava J, Levesque C, Sherman P, Glogauer M. Identification of Quantitative Trait Loci Influencing Inflammation-Mediated Alveolar Bone Loss: Insights into Polygenic Inheritance of Host-Biofilm Disequilibria in Periodontitis. Journal of Periodontal Research 2015; 51:237-249.

  • Aboodi GM*, Sima C*, Moffa EB, Crosara KTB, Xiao Y, Siqueira WL, et al. (2015). Salivary Cytoprotective Proteins in Inflammation and Resolution during Experimental Gingivitis—A Pilot Study. Frontiers in Cellular Infection and Microbiology 2015; 5:856. *equal contribution

  • Su Q, Sima C, Lakschevitz F, Selzter Z. and Glogauer M. New Quantitative Trait Loci for Neutrophil Recruitment in Sterile Inflammation Identified in Axb-Bxa Recombinant Inbred Mice. PloS One 2015; 10(5), e0124117

  • Zamakhchari MF, Sima C*, Sama K, Fine N, Glogauer M, Van Dyke TE, and Gyurko R. Lack of p47phox in Akita Diabetic Mice is Associated with Interstitial Pneumonia, Fibrosis, and Oral Inflammation. American Journal of Pathology 2016; 186:659–670. *equal contribution

  • Sima C*, Aboodi, G.M.*, Lakschevitz F.S., Sun C, M.B. Goldberg, Glogauer M. Nrf2 Downregulation in Oral Neutrophils is Associated with Periodontal Oxidative Damage and Severe Chronic Periodontitis. American Journal of Pathology 2016; 186(6):1417-26.

  • Fine N, Hassanpour S, Borenstein A, Sima C, Oveisi M, Scholey J, Cherney D, Glogauer M. Distinct Oral Neutrophil Subsets Define Health and Periodontal Disease States. Journal of Dental Research 2016; 95:931–938.

  • Revelo XS, Ghazarian M, Chng MHY, Luck H, Kim JH, Zeng K, Shi SY, Tsai S, Lei H, Kenkel J, Kenkel J, Long Liu C, Tangsombatvisit S, Tsui H, Sima C, Xiao S, Shen L, Li X, Jin T, Gary GF, Woo M, Utz PJ, Glogauer M, Engleman E, Winer S, and Winer DA. Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance. Cell Reports 2016; 16(3):717-730 

  • Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan CN and Van Dyke TE. ERV1 Overexpression in Myeloid Cells Protects against High Fat Diet Induced Obesity and Glucose Intolerance. Scientific Reports 2017; 7(1):12848.

  • Viniegra A, Goldberg H, Çil Ç, Fine N, Sheikh Z, Galli M, Freire M, Wang Y, Van Dyke TE, Glogauer M and Sima C. Resolving Macrophages Counter Osteolysis by Anabolic Actions on Bone Cells. Journal of Dental Research 2018; 97(10):1160-1169. 

  • Montero E., Herrera, D., Sanz, M., Dhir. S., Van Dyke, TE and Sima C. Development and Validation of a Predictive Model for Periodontitis using NHANES 2011-2012 Data. Journal of Clinical Periodontology 2019; 46(4):420-429.

  • Choi S.E., Sima C. & Pandya A. Impact of Treating Oral Disease on Preventing Vascular Diseases: A Model-Based Cost-Effectiveness Analysis of Periodontal Treatment Among Patients with Type 2 Diabetes. Diabetes Care 2019; 46(4):420-429.

  • Wzatek M, Bahammam S, Buiga P, Haddad K, Sima C. Oral Neutrophil Free Fatty Acid Receptors Expression May Link Oral Host and Microbiome Lipid Metabolism. Frontiers in Oral Health 2022; 3: 821326

  • Muruganandan S, Pierce R, Teguh D, Perez R.F., Bell N, Nguyen B, Hohl K, Snyder B, Grinstaff M, Alberico H, Woods D, Y Kong, Sima C, Bhaga St, Ho K, Rosen V, Gamer L,  Ionescu A. Growth Plate Long-Term Self-Renewing Stem Cell Population Contributes to Regeneration of Injured Physis. Journal of Bone and Mineral Research 2022; 37:1

  • Saggu A, Maguluri M, Grimble J, Park J, Hasturk H, Iftimia N, Sima C. Raman Microspectroscopy/Micro‐Optical Coherence Tomography Approach for Chairside Diagnosis of Periodontal Diseases: A pilot study. Journal of Periodontology 2022; 

  • Muruganandan S, Pierce R, Teguh D, Perez R.F., Bell N, Nguyen B, Hohl K, Snyder B, Grinstaff M, Alberico H, Woods D, Y Kong, Sima C, Bhaga St, Ho K, Rosen V, Gamer L, Ionescu A. A FoxA2+ Long-Term Stem Cell Population is Necessary for Growth Plate Cartilage Regeneration after Injury. Nature Communications 2022; 13(1):1-15

  • Choi SE, Sima C, Pesquera Colom L, Nguyen GN, Giannobile WV. Evaluation of Comprehensive COVID-19 Testing Program Outcomes in a US Dental Clinical Care Academic Setting. Journal of The American Medical Association Network Open 2022: e2246530-e2246530.

Reviews & Book Chapters

  • Sima C and Glogauer M. Periodontitis in Patients with Diabetes – a Complication that Impacts on Metabolic Control. US Endocrinology 2012; 8(1): 35-39.

  • Sima C and Glogauer M. Macrophage Subsets and Osteoimmunology: Tuning of the Immunological Recognition and Effector Systems that Maintain Alveolar Bone. Periodontology 2000 2013; 63(1): 80-101.

  • Sima C and Glogauer M. Diabetes Mellitus and Periodontal Diseases. Current Diabetes Reports 2013; 13(3): 445-452.

  • Sima C and Glogauer M. Neutrophil Dysfunction and Host Susceptibility to Periodontal Inflammation: Current State of Knowledge. Current Oral Health Reports 2014; 1(2):95-103.

  • Sheikh Z, Sima C and Glogauer M. Techniques and Materials used for Achieving Vertical Alveolar Bone augmentation. Materials 2015; 8(6), 2953-2993

  • Sima C and Van Dyke TE. Therapeutic Targets for Management of Periodontitis and Diabetes. Current Pharmaceutical Design. Current Pharmaceutical Design 2016; 22:2216–2237.

  • Sima C, Paster B and Van Dyke TE. Function of Pro-Resolving Mediator Resolvin E1 in Type 2 Diabetes. Critical Reviews in Immunology 2018; 38(5):1-23

  • Sima C and Van Dyke TE. Systems Medicine and Periodontal Diseases. Translational Systems Medicine and Oral Disease 2019; Chapter 12; Editors: Sonis and Villa.

  • Van Dyke TE. & Sima C. Understanding resolution of inflammation in periodontal diseases: Is chronic inflammatory periodontitis a failure to resolve. Periodontology 2000 2020 82, 205-213.

  • Romandini M, Bahammam S, Rodrigo D, Sima C and Montero E. Impact of the Systemic Status on the Development and Progression of Peri-Implant Diseases. Spanish Society of Periodontology 2020

  • Steigmann L, Maekawa S, Sima C, Travan S, Wang J, Giannobile W. Biosensor and Lab-on-a-chip Biomarker-identifying Technologies for Oral and Periodontal Diseases. Frontiers in Pharmacology – Translational Pharmacology 2020 9;11:588480.

  • M Brock, S Bahammam, Sima C. The Relationships Among Periodontitis, Pneumonia and COVID-19. Frontiers in Oral Health 2021; 2: 801815

Abstracts & Presentations

  • “Chronic Hyperglycemia Impairs Leukocyte Recruitment to Sites of Inflammation”, poster by Sima C et al, the IADR General Session , Miami, FL, USA. 2009

  • "Resolvin E1 actions on polymorphonuclear neutrophils in type 1 diabetes mellitus", a seminar presented by Sima C at the Matrix Dynamics Group, University of Toronto, Toronto, ON, Canada. 2010

  • "Roles of Rac1 and Rac2 in Alveolar Bone Loss In Vivo", poster by Sima C et al, the University of Toronto Faculty of Dentistry Research Day, Toronto, ON, Canada. 2011

  • "Rac Null Leukocytes are Associated with Increased Alveolar Bone Loss", poster by Sima C et al, the IADR General Session (Hatton competition, senior basic science), Cape Town, South Africa. 2014 

  • "Macrophage Plasticity in Osteolytic Inflammatory Diseases – The Case of Periodontitis", a seminar presented by Sima C at The Forsyth Institute, Cambridge, MA, USA. 2014

  • "Mouse Models to Study the Onset, Progression and Resolution of Periodontal Inflammation", a seminar presented by Sima C at Scholar Rock, Inc., Cambridge, MA, USA. 2015

  • "Macrophage Polarization in Experimental Periodontitis”, poster by Sima C et al, the NIDCR Trainee Session, Boston, MA, USA. 2015

  • "M2-Polarized Macrophages Mediate Healing of Inflammation-Mediated Alveolar Bone Loss", poster by Sima C et al, the AADR General Session NIDCR Trainee Session, Los Angeles, CA, USA. 2016

  • "Gingivitis and periodontitis mouse models of chronic inflammation", a seminar presented by Sima C at the Institute of Dentistry, Barts and The London School of Medicine and Dentistry, London, UK. 2016

  • "Resolution Programming in Diet-Induced Obesity, Insulin Resistance and Periodontitis through Modulation of Monocyte/Macrophage Activation", a seminar presented by Sima C at the University of California San Francisco School of Dentistry, San Francisco, CA, USA. 2017

  • "Advancing Periodontology in the Era of Precision Medicine", seminar presented by Sima C at the University of North Carolina, School of Dentistry, Chapel Hill, NC, USA. 2017

  • "Monocyte-Macrophage States in Health and Disease", a symposium talk by Sima C at the IADR General Session Symposium on “Innate Immune Cell Heterogeneity in Health and Disease”, London, UK. 2018

  • “Oral Neutrophil Free Fatty Acid Receptor Expression”, poster by Buiga P et al, the Forsyth Symposium, The Forsyth Institute, Cambridge, MA, USA. 2019

  • Lecture series given by Sima C to DMD students in Periodontal Immunology, Timing of Implant Placement, Periodontal Therapy in Medically Complex Patients and Periodontal-Systemic Connections at the Univeristy Immersion Program, Sichuan University, Chengdu, China. 2019

  • “RMS/mOCT Probe for Chairside Diagnosis of Periodontal Diseases”, poster by Saggu A et al, a finalist at the AAP Clinical Research Poster Competition. 2020 (remote)

  • “Resolving Macrophages Regulate Adiposity and Energy Expenditure on High-Fat Diet”, a poster by Bahammam S et al, the IADR General Session. 2021 (remote)

  • “Oral Neutrophil Free Fatty Acid Receptors”, poster by Haddad K et al, the IADR General Session. 2021 (remote)

  • “Validation of a Combined RMS-mOCT Optical Probe for Periodontal Assessment”, poster by Saggu A et al, the IADR General Session. 2021 (remote)

  • “The Impact of COVID-19 on Harvard Dental Center Services” poster by Brock M et al, IADR General Session. 2021 (remote)

  • “Resolving Macrophages Regulate Adiposity and Energy Expenditure on High-Fat Diet” poster by Bahammam S et al at the AAP Annual Meeting, Miami, FL, USA - Winner of the Basic Science Competition. 2021

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We Rise by Lifting Others

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